Mladen J. Kocica, MD

"We can not do great things, just small things with great love"

HVMB Anatomy
HVMB Physiology
HVMB Prospects
F. Torrent-Guasp

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HVMB Physiology


"Form ever follows function".

Louis H. Sullivan (1856-1924)


Contemporary science has to adopt a new way of thinking, which has emerged from rapid accumulation of knowledge at different levels. By completing the "Book of Life" in 2003, one of the main challenges in physiology over the next 10 years will be the interpretation of the genome and ascribing physiological function to genes and proteins in the wider context of integrative systems. Human genome project, along with achievements in other biological and non-biological sciences, has imposed a paradigm shift in anatomy and physiology, necessitating integration and linking across multiple scales of biological organization - from proteins to cells, tissues, organs and organ systems - in order to understand a complexity of interactions between form and function, generating a specific behavior (normal or abnormal) in biological system (Physiome Project).

Peter J. Hunter and Thomas K. Borg. Integration from proteins to organs - the Physiome Project. Nature Reviews 2003;4:237-243.


“Nature creates why, humans find how. If how does not explain why, find another how”.

Gerald D. Buckberg

During the last decade, three successive, international, multidisciplinary symposia (Alicante 1995; Bethesda 2002 and Liverpool 2005) were organized with common task - to set up fundamental research principles, which would allow us to make a significant step forward in understanding heart structure and function.

Torrent-Guasp's HVMB has been widely studied as anatomical model underlying electrical and mechanical activity of the heart. 


Below you may find recent review papers describing current knowledge of HVMB physiology:

Torrent-Guasp F, Kocica MJ, Corno A, Komeda M, Cox J, Flotats A, Ballester-Rodes M, Carreras-Costa F.
Systolic ventricular filling.
Eur J Cardiothorac Surg 2004;25(3):376-386.


Gerald D. Buckberg, Heinz Schelbert, Aman Mahajan.
Cardiac motion and fiber shortening: the whole and its parts.
Eur J Cardiothorac Surg 2006;29:S145-S149.


Gerald D. Buckberg, Manuel Castellá, Morteza Gharib, Saleh Saleh.
Active myocyte shortening during the ‘isovolumetric relaxation’ phase of diastole is responsible for ventricular suction; ‘systolic ventricular filling’.
Eur J Cardiothorac Surg 2006;29:S98-S106.


Gerald D. Buckberg, Manuel Castellá, Morteza Gharib, Saleh Saleh.
Structure/function interface with sequential shortening of basal and apical components of the myocardial band.
Eur J Cardiothorac Surg 2006;29:S75-S97.


John P. Boineau.
Left ventricular muscle band (VMB): thoughts on its physiologic and clinical implications.
Eur J Cardiothorac Surg 2006;29:S56-S60.


Copyright © 2006 Mladen J. Kocica, MD. All rights reserved.